An introduction to paired-difference procedures. I briefly discuss how paired difference scenarios arise, and briefly outline how we can use the paired-difference t procedure to construct confidence intervals and carry out hypothesis tests. (Paired difference procedures are sometimes referred to as matched-pairs procedures, depending on the setting.)
The alcohol/reaction time data is loosely based on information in:
Anderson et al. (2011). Functional Imaging of Cognitive Control During Acute Alcohol Intoxication. Alcoholism: Clinical and Experimental Research, 35(1):156-165.
The identical twin-schizophrenia data is from:
Suddath et al. (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine, 322:789-794. Values used in this video are simulated values based on the summary statistics found in the paper.